Dias-Ferreira, E., Sousa, J.C., Melo I., Morgado P., Mesquita, A.R., Cerqueira J.J., Costa, R.M. Sousa N. (2009). Chronic stress causes frontostriatal reorganization and impairs decision making. Science, 325(5940):621-5.
Yin, H.H., Prasad-Mulcare, S., Hilario, M.R.F., Clouse, E., Davis, M. I., Lovinger, D.M.., Costa, R.M. (2009). Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. Nature Neuroscience, 12:3.
Cui, Y., Costa R. M., Murphy G. G., Elgersma, Y., Zhu, Y., Gutmann, D.H., Parada, L.F., Mody, I., Silva A. J. (2008). Neurofibromin regulation of Ras/ERK signaling modulates GABA release and learning. Cell, 31;135(3):549-60.
Hilario, M., Clouse, E., Yin, H.H., Costa,
R.M. (2007). Endocannabinoid
signaling is critical for habit formation. Frontiers
in Integrative Neuroscience. 1: 6, doi:
10.3389/neuro.07/006.2007.
Costa, R.M., Lin, S.C., Sotnikova, T.D., Cyr,
M., Gainetdinov, R.R., Caron, M.G., Nicolelis M.A.L. (2006). Rapid
alterations in corticostriatal ensemble coordination during acute
dopamine-dependent motor dysfunction. Neuron,
52(2): 359-69.
Costa, R.M., Drew, C. and Silva, A.J. (2005). To Remember or Notch to Remember. Trends
in Neurosciences, 28: 429-35.
Costa, R.M.*, Cohen, D.*, Nicolelis M.A.L. (2004). Differential
corticostriatal plasticity during fast and slow motor skill learning in
mice. Current
Biology, 14(13): 1124-34.
Costa R.M., Honjo T., and Silva A.J. (2003). Learning and memory deficits
in Notch mutant mice. Current Biology, 13 (15): 1348-54.
Costa, R.M. and Silva, A.J. (2003). Mouse models of Neurofibromatosis
type I: Bridging the GAP. Trends in Molecular Medicine,
9: 19-23.
Costa, R.M., Federov, N.B., Kogan, J.H., Murphy, G.G.,
Stern, J., Ohno, M., Kucherlapati, R., Jacks, T. and Silva, A.J. (2002).
Mechanism for the learning deficits in a mouse model of neurofibromatosis
type 1. Nature,
415 (6871): 526-30.
Costa, R.M.*, Yang, T.*, Huynh, D.P., Pulst S.M., Viskochil, D.H., Silva,
A.J. and Brannan, C.I. (2001). Learning deficits, but normal development
and tumor predisposition, in mice lacking exon 23a of the Neurofibromatosis
type I gene. Nature Genetics, 27: 399-405.
All Publications
Burkhardt, J.M., Jin, X, and Costa R.M (2009). Dissociable effects of dopamine on the firing rate and synchrony of striatal ensembles. Front. Integr. Neurosci., 3:28. doi:10.3389/neuro.07.028.2009.
Dias-Ferreira, E., Sousa, J.C., Melo I., Morgado P., Mesquita, A.R., Cerqueira J.J., Costa, R.M. Sousa N. (2009). Chronic stress causes frontostriatal reorganization and impairs decision making. Science, 325(5940):621-5.
Yin, H.H., Prasad-Mulcare, S., Hilario, M.R.F., Clouse, E., Davis, M. I., Lovinger, D.M.., Costa, R.M. (2009). Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. Nature Neuroscience, 12:3.
Cui, Y., Costa R. M., Murphy G. G., Elgersma, Y., Zhu, Y., Gutmann, D.H., Parada, L.F., Mody, I., Silva A. J. (2008). Neurofibromin regulation of Ras/ERK signaling modulates GABA release and learning. Cell, 31;135(3):549-60.
Hilário, M.R.F and Costa, R.M. (2008). High on Habits. Frontiers in Neuroscience, 2,2:208-21.
Groszer, M., Keays, D.A., Deacon R.M.J., de Bono J.P., Prasad-Mulcare S., Gaub, S., Baum, M.G., French, C.A., Nicod, J., Coventry, J.A., Enard, W., Fray, M., Brown, S.D.M., Nolan, P.M., Pääbo, S., Channon, K.M., Costa, R. M., Eilers, J., Ehret, G., J., Rawlins N.P., Fisher, S.E. (2008). Impaired motor learning and synaptic plasticity in mice carrying a point mutation implicated in human speech deficits. Current Biology, 18(5): 354-62.
Hilario, M., Clouse, E., Yin, H.H., Costa, R.M. (2007) Endocannabinoid
signaling is critical for habit formation, Frontiers in Integrative
Neuroscience 1: 6, doi: 10.3389/neuro.07/006.
Wickens, J.R., Horvitz, J.C., Costa, R.M., Killcross, S (2007) Dopaminergic
mechanisms in actions and habits, Journal of Neuroscience 27: 8181-3.
Costa, R.M. (2007) Plastic corticostriatal circuits for action learning:
What’s dopamine got to do with it?, Annals of the New York Academy
of Sciences, 1104: 172-91.
Dzirasa, K., Ribeiro. S., Costa, R.M., Santos, L.M., Lin, S.C., Grosmark,
A., Sotnikova, T.D., Gainetdinov, R.R., Caron, M.G., Nicolelis
M.A.L. (2006) Dopaminergic Control of Sleep-Wake States, Journal of Neuroscience,
26(41): 10577-89.
Costa, R.M., Lin, S.C., Sotnikova, T.D., Cyr, M., Gainetdinov, R.R., Caron,
M.G., Nicolelis M.A.L. (2006) Rapid alterations in corticostriatal ensemble
coordination during acute dopamine-dependent motor dysfunction. Neuron 52(2):
359-69.
Costa, R.M., Gutierrez, R., Kloth, A., Coelho, M.R.P., de Araujo, I.E.,
Gainetdinov, R.R., Caron, M.G., Nicolelis M.A.L., Simon, S.A. (2006)
Dopamine levels modulate the updating of tastant values. Genes,
Brain and Behavior. 6(4): 314-20.
Nagy, V., Bozdagi, O., Matynia, A., Balcerzyk, M., Okulski, P., Dzwonek,
J., Costa, R.M., Silva, A. J., Kaczmarek, L., and Huntley G. W.
(2006) Matrix metalloproteinase (MMP)-9 is required for hippocampal
late-phase LTP and memory. Journal of Neuroscience 26: 1923-1934.
Costa, R.M., Liu, L., Nicolelis, M.A.L., Simon, S.A. (2005) Gustatory
Effects of Capsaicin that are Independent of TRPV1 Receptors. Proc.
ISOT XIV, Chemical Senses 30 S1: i198-i200.
Costa, R.M., Drew, C. and Silva, A.J. (2005) To Remember or Notch to Remember.
Trends in Neurosciences, 28: 429-35.
Costa, R.M,. and Silva, A.J. (2004) Learning Deficits associated with
NF1: from models to therapies. in Neurofibromatose: Clínica, Genética
e Terapêutica , Ed. Mauro Geller, Editora Guanabara Koogan SA , Rio
de Janeiro, Brazil (Portuguese).
Costa, R.M., Cohen, D., Nicolelis M.A.L. (2004) Differential corticostriatal
plasticity during fast and slow motor skill learning in mice. Current
Biology 14(13): 1124-34.
Israely, I., Costa, R.M., Silva, A.J., Kosik, K., Liu, X. (2004) Deletion
of the neural specific protein Delta-Catenin leads to severe cognitive
and synaptic dysfunction. Current Biology 14(18): 1657-63.
Ajay A., Costa R.M., Irvin D., Patel A., Hu H., Kornblum H., Silva A.J.,
O’Dell T., and Colicelli J. (2003). The RAS Effector RIN1 Modulates
the Formation of Aversive Memories, Journal of Neuroscience, 23
(3): 748-757.
Frankland, P.W., Ohno M., Takahashi, E., Chen, A.P., Costa R.M., Kushner,
S.A. and Silva, A.J. (2003). Synomics: Pharmacologically Regulated
Induction of Silent Mutations (PRISM): Combined pharmacological
and genetic approaches for learning and memory. , The Neuroscientist, 9:
104-9.
Costa R.M., Honjo T., and Silva A.J. (2003) Learning and memory deficits
in Notch mutant mice. Current Biology 13 (15): 1348-54.
Costa, R.M. and Silva, A.J. (2003) Mouse models of Neurofibromatosis type
I: Bridging the GAP. Trends in Molecular Medicine, 9: 19-23.
Costa, R.M., Elgersma, Y. and Silva, A.J. (2003. of Neurobehavioral Disorders,
Ed. Gene Fisch, Humana Press, Totowa, NJ, USA.
Costa, R.M., Federov, N.B., Kogan, J.H., Murphy, G.G., Stern, J., Ohno,
M., Kucherlapati, R., Jacks, T. and Silva, A.J. (2002) Mechanism
for the learning deficits in a mouse model of neurofibromatosis
type 1, Nature, 415 (6871) 415 (6871): 526-30.
Costa, R.M. (2002) Molecular and cellular mechanisms of cognitive dysfunction
in Neurofibromatosis type I. Thesis. Abel Salazar Biomedical Institute,
University of Porto, Portugal.
Costa, R.M. and Silva, A.J. (2002) Molecular and cellular mechanisms underlying
the cognitive deficits associated with Neurofibromatosis type I,
Journal of Child Neurology, 17: 622-626.
Givogri M.I., Costa R.M., Schonmann V., Howard S., Silva A.J., Campagnoni
A.T., Bongarzone E.R. (2002) The Jagged/Notch pathway is critical
for oligodendrocyte differentiation and myelination in vivo., Journal
of Neuroscience Research, 67 (3): 309-20.
Costa, R.M., Yang, T., Huynh, D.P., Pulst S.M., Viskochil, D.H., Silva,
A.J. and Brannan, C.I. (2001) Learning deficits, but normal development
and tumor predisposition, in mice lacking exon 23a of the Neurofibromatosis
type I gene, Nature Genetics, 27: 399-405.
Silva, A.J., Elgersma, Y. and Costa, R.M. (2001) From genes to therapies:
the role of animal models. Clinical Neuroscience Research, 1: 187-193.
Ohno, M., Frankland, P.W., Chen, P.A., Costa R.M. and Silva A.J. (2001)
Inducible pharmacogenetic approaches to the study of learning and
memory. Nature Neuroscience, 4: 1238-1243.
Silva, A.J., Elgersma, Y. and Costa, R.M. (2000) Molecular and Cellular
Mechanisms of Cognitive Function: Implications for Psychiatric
Disorders., Biological Psychiatry, 47: 200-210.
Mayntz, M. and Costa, R. (1998) Effect of pharmacologically induced changes
of ejection on suckling in Bos taurus. , Physiology and Behavior,
65 (1): 151-156.
Costa, R., Mayntz, M. and Sender, G. (1998) Changes of milk compounds
and fatty acid composition during suckling meals and the effect
of after-stimulation on fatty acid composition in cows' milk. ,
A pre-study. Milchwissenchaft, 53 (8): 430-434.